MEN Syndromes
Answers to common questions about men syndromes.
Questions on this page
What does MEN mean?
MEN stands for Multiple Endocrine Neoplasia.
These are inherited conditions in which people have an increased tendency to develop certain endocrine tumours.
What is MEN1?
MEN1 is an inherited disorder commonly associated with tumours involving:
- Parathyroid glands
- Pituitary gland
- Pancreatic or other gastroenteropancreatic neuroendocrine tissues
What is MEN2?
MEN2 is associated particularly with:
- Medullary thyroid carcinoma
- Phaeochromocytoma
- Primary hyperparathyroidism in some forms
Can MEN run in families?
Yes. MEN syndromes are inherited genetic conditions and family evaluation can be very important.
Does having MEN mean I will definitely develop every tumour?
No. The specific genetic mutation and syndrome determine the pattern of risk.
Why is genetic testing important in MEN?
Identifying the causative genetic variant can help determine who in the family requires surveillance and, in some conditions, preventive treatment.
Should relatives of a person with MEN be tested?
When a disease-causing genetic variant has been identified, targeted testing of appropriate relatives can be extremely useful.
Can MEN be cured?
The genetic predisposition cannot currently be removed, but regular surveillance and appropriate treatment can detect endocrine tumours early and reduce complications.